1. Pier 39, Scoma's (for dinner), Boudin Bakery (sourdough is delicious), Ghiradelli (free chocolate bar every time you walk in), Pier 23 Cafe (a Diners, Drive-ins, and Dives pick), Alcatraz (awesome audio tour), cable car ride, wine country tour, Lombard Street, Painted Ladies, and Muir Woods are all must-sees.